Allulose: A Key Anti-Aging Sweetener

  • by Nils Osmar. April 5, 2024
  • This post is not intended as, and should not be taken as, medical advice. 
  • See full Medical Disclaimer

Allulose is marketed as a low calorie sweetener. Recent studies suggest that it also has anti-aging properties, including activating AMPK (a metabolic pathway associated with slower aging and prolonged lifespan); increasing insulin sensitivity; improving mitochondrial biogenesis; lowering blood glucose; improving endurance following exercise; and (surprise) supporting muscle protein synthesis.

From a recent study:

Our data suggested the combination of exercise training and D‐allulose intake as an effective strategy to upregulate endurance capacity in mice. This may be associated with sparing glycogen content and enhancing activation of AMPK‐ACC signaling in the skeletal muscle.

From a recent Healthline article:

In a study comparing the effects of consuming allulose, cellulose, and a commercial diet in rats with insulin resistance, the allulose group had improved insulin sensitivity after 7 weeks (6). Early research also suggests that allulose may have beneficial effects on blood sugar regulation in humans (8).

In one study, 30 participants without diabetes received a 50-g dose of sucrose followed by either a placebo or allulose. The allulose group experienced significantly lower blood sugar levels after 30 minutes than the placebo group, though this difference was not maintained at later time points (8)….

Animal and human studies suggest that allulose may lower blood sugar levels, increase insulin sensitivity, and help protect the insulin-producing pancreatic beta cells.

Related study: D-allulose ameliorates adiposity through the AMPK-SIRT1-PGC-1α pathway in HFD-induced SD rats

Results: Rats receiving AP and AL showed reduced body weight gain and fat accumulation in HFD-fed rats. Also, supplementation of AL/AP regulated the cytokine secretion and recovered biochemical parameters to alleviate metabolic dysfunction and hepatic injury.

Additionally, AL/AP administration improved adipocyte differentiation via regulation of the PPARγ and C/EBPα signaling pathway and adipogenesis-related genes owing to the combined effect of the AMPK/SIRT1 pathway. Furthermore, AL/AP treatment mediated PGC-1α expression triggering mitochondrial genesis via activating the AMPK phosphorylation and SIRT1 deacetylation activity in adipose tissue.

Conclusion: The anti-adiposity activity of D-allulose is observed on a marked alleviation in adipogenesis and AMPK/SIRT1/PGC-1α deacetylation in the adipose tissue of HFD-fed rat.

My thoughts:

  • Age related muscle loss kicks in when we’re in our 40s and accelerates as the years go by. At my age (71 in April of 2024), I’m in danger of gradually losing muscle even though I work out hard in my home gym.
  • Taking anabolic supplements and eating ample protein rich in leucine (timed around workouts) is my core strategy for maintaining muscle. But it’s important to me to also be activating AMPK part of the time, so I don’t trade off the anabolic benefits of a high protein diet for the life extension benefits of activating AMPK.
  • Allulose looks promising because it supports muscle growth and supports the activation of AMPK. (Many AMPK activators (including berberine and metformin) have been found to suppress muscle protein synthesis. It’s interesting to find one that (the evidence suggests) supports it.
  • As is usually the case, more human studies are needed. Till they’re completed, because allulose is generally regarded as safe to consume, I’ve added it to my protocol. I use it to sweeten the dark cherries and wild blueberries I add to L. Reuteri yogurt for an afternoon snack.

Not medical advice

This article is not intended as, and should not be taken as, medical advice. I’m not advising that people eat any particular diet or take any particular supplement(s), just reporting on what I’m doing. Supplements, like medications and other interventions, can have side effects; I would encourage people to research both possible benefits and side effects before starting on any supplementation regimen, and consult with a medical professional about any issues which might have a medical component.  See full Medical Disclaimer

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