by Nils Osmar. March 2, 2022
Fisetin is used as a senolytic by many in the life extension community. Taken in a large dose, it’s been shown to be effective at clearing senescent cells from both the brain and body. According to a study called Fisetin is a senotherapeutic that extends health and lifespan:
“Of the 10 flavonoids tested, fisetin was the most potent senolytic. Acute or intermittent treatment of progeroid and old mice with fisetin reduced senescence markers in multiple tissues, consistent with a hit-and-run senolytic mechanism.
‘Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.”
Bear in mind of course that this was an animal study. More studies are needed to verify its effectiveness in humans.
Could it also have other uses?
According to some recent animal studies, the answer is yes. It appears to provide protection against diseases such as cancers, diabetes, and alcohol-induced liver injury. It also alleviates airway inflammation, making it useful for conditions such as asthma.
From the study:
“Flavonoids, like fisetin, are a class of secondary metabolites produced by plants, which are known to have numerous beneficial effects. .”
“Fisetin has been reported to exhibit various positive biological effects, including anti-proliferative, anticancer, anti-oxidative and neuroprotective effects. We evaluated the effects of fisetin on allergic asthma regulation in mice.”
- I’ve taken fisetin in combination with quercetin several times hoping for a senolytic effect. The first time, I took three grams of each along with water. (Some people prefer taking them along with food.)
- It’s hard to know what’s happening internally. I did get a headache that lasted about a half hour, then felt fine. I’m hoping some senescent cells were cleared.
- Re: airway inflammation, I don’t have asthma, but I do get stuffed up during allergy season. My symptoms can get pretty severe, so I can tell immediately whether an intervention is working. I have gotten good results fisetin and quercetin together. I sometimes also take NAC along with them. My breathing gets clearer and other allergy symptoms are usually decreased within an hour after taking them.
- There are several good brands, I’m currently taking NAC from LifeExtension along with fisetin and quercetin from DoNotAge. The combination works well for me. I take 1 or 2 grams of each (together) during allergy season. (Reminder: Nothing in this website is intended as, or should be taken as, medical advice.)
- Fisetin is a senotherapeutic that extends health and lifespan:
- Orally administered fisetin as an immuno-modulatory and therapeutic agent in a mouse model of chronic allergic airway disease
- Fisetin-treatment alleviates airway inflammation through inhbition of MyD88/NF-κB signaling pathway