Meals for Longevity: Fasting-Mimicking Smoothies


by Nils Osmar. Updated 10/19/2022. Medical disclaimer

A fasting mimicking smoothie is essentially a type of liquid fasting mimicking diet (FMD). You can drink one when you’re doing an FMD, or on any day or morning when you want the benefits of fasting but don’t feel like doing a water fast.

Note that fasting mimicking diets (and smoothies) are not permanent diets. They don’t provide enough nutrients to support health indefinitely. They are temporary diets designed to mimic the effects of fasting while supporting both weight loss and autophagy.

I’ve done some long (3-5 day) fasts, and have also done several pseudo-fasts in which I drank one or two of these smoothies a day. They were my only nutrition. I found that they completely controlled my hunger while supporting AMPK activation, which gave me all of the energy I need.

I find this smoothie to be delicious, and view it as part of my anti-aging protocol. It has ingredients that raise NAD levels, activate the sirtuin genes, and support stem cell regeneration and differentiation, particularly when I drink it along with the supplements I mention below the ingredients list.

Keeping AMPK activated

One goal of fasting is to switch on AMPK (the longevity pathway) and keep it activated.

From one POV, AMPK is our natural state. It’s our default state when we’re not eating. Most of wake up in the mornings with AMPK at least somewhat activated, simply because it’s been hours since our last meal. (Our “fast” after eating dinner will have switched AMPK on, and switched mTOR off.)

We can stay in this AMPK state by delaying breakfast, or by eating a very low protein, plant-based breakfast, or by drinking a fasting mimicking smoothie of this sort.

This smoothie has about 5 grams of net carbs (so won’t take you out of ketosis); has 5 grams of plant-based protein (so it won’t take you out of autophagy); has almost no leucine (so it won’t switch off AMPK). It also has several grams of healthy fat from the avocado.

I’m not vegan, but I do like eating vegan meals now and then, and timing them to keep AMPK switched on. I either fast, or eat a vegan meal, or drink a smoothie like this, in the morning; then work out; then after my workout have a meal to activate mTOR for a while. This smoothie is a highly nutritious plant-based meal in a glass.

The Recipe

Combine in a blender. Blend on high for a couple of minutes. It’ll be pretty thick; add another cup of water or celery juice if you’d like it thinner.

  • 1 or 2 cups of water (or you could try using celery juice)
  • 1/2 to 1 tomato (rich in lypocene; anti-cancer) or 8 cherry tomatoes
  • 1/2 to 1 ripe avocado (rich in oleic acid, which activates the sirtuin 1 gene)
  • 1 or 2 scoops of green powder. I use Ora Easy Being Green. Here you have to be careful, because some green powders are too high in protein; but some kinds of proteins can switch us out of an AMPK state and turn on mTOR. I use Ora Organic Greens powder because it contains only 2 grams of protein, less than one gram of leucine, and less than 3 grams of net carbs.
  • A dash of Redmond Realsalt (a “sea salt” without micro-plastics)
  • 1/2 teaspoon dried parsley (optional) (for apigenin – raises NAD levels)
  • 1 teaspoon dried rosemary (optional) (a primary staple of the villagers in Acciaroli, which has the world’s highest rate of centenarians)
  • 1 teaspoon of Gaia Herbs Black Elderberry Syrup (activates the SIRT1 gene)
  • Optional: garlic. (I add 3 lobes of peeled garlic)
  • Optional: 1/4 teaspoon of malic acid powder (key to energy production in the Krebs cycle) (Caution: malic acid is very sour. I would start with a tiny amount)
  • Optional: 1/4 cup of berries (or: 1 teaspoon each of blueberry powder and pomegranate powder)

I drink the smoothie along with these supplements:

  • 1 or 1.5 grams of NMN powder. (I actually just add the NMN powder to the smoothie.) (The NMN I take is from DoNotAge)
  • 1 capsule of resveratrol (500 mg) (from DoNotAge) (I take the resveratrol every other day.)
  • 2 or 3 capsules of fucoidan (I’m currently taking DoNotAge SIRT6 Activator, a type of fucoidan which has been tested in Dr. Vera Gorbunova’s lab to verify that each batch is activating the sirtuin 6 gene; batches that don’t activate sirtuin 6 are discarded)
  • 1 capsule PQQ (20 mg) (from Health Through Nutrition)
  • 4 capsules of astaxanthin (an AMPK activator) (Mine is from Gaia Herbs)
  • 1 capsule BioGaia Gastrus or Osfortis (a source of L. Reuteri 6475)
  • 1 capsule sulforaphane (I’m currently using DoNotAge sulforaboost)
  • 4 capsules Jarrow Glucosamine and Chondroitan (Glucosamine is another powerful AMPK activator, which has potent anti-aging efffects of its own)
  • Optional: 1 500 mg capsule NR (if you’d like a little more NAD+ boosting) (I’m currently using DoNotAge NR)
  • Optional: 1 capsule Fisetin (I’m currently using DoNotAge)
  • Optional: 1 capsule Quercetin (I’m currently using DoNotAge)

If I’m doing a fasting day and want to activate autophagy and blast my senescent cells, I’ll take 5 capsules each of the fisetin and quercetin (I do this four or five times a year). The brand names I’ve mentioned are ones I like and have gotten good results from. If using other brands, try to verify that they’re genuine ingredients and high quality.

Benefits of Fasting and Fasting Mimicking Diets

Water fasting has a number of well-established benefits. Benefits of a 3 to 5 day water fast include:

  • Supporting weight loss
  • Reducing belly fat
  • Improving some markers of cardiovascular health
  • Reducing inflammation
  • Improving autoimmune markers
  • Removing senescent cells (and supporting the growth of new stem cells which occurs at the end of the fast)
  • Supporting nutritional ketosis
  • Improving blood sugar
  • Improving insulin sensitivity
  • Fasting also appears to reduce some of the side effects of chemotherapy, such as nausea
  • Animals studies suggest that periodic fasting may also support a longer lifespan, by lowering mTOR activation and supporting the activation of AMPK.

However, water fasts are difficult for some people to do. And some doctors have expressed a concern that they might lead to nutrient deficiencies over time. One alternative is –

Fasting Mimicking Diets

According to Dr. Valter Longo, fasting mimicking diets (FMDs) have identical benefits (and may be safer, particularly for the elderly, who are sometimes already eating nutritionally-borderline diets). But FMDs can be expensive (the ProLon diet is very pricey), and can be a little hard for some people to follow.

There are several different kinds of FMDs, but in my opinion. to have a chance of working, they all need to be: high in fat; low in carbs; very low in protein (under 16 grams per day); and vegan. (I’m not a vegan full time anymore, but I’m wholeheartedly vegan, in dietary terms, on FMD days. Animal-based foods are high in leucine, an amino acid that can pull us out of autophagy and start activating mTOR. mTOR activation is good for building muscle, but is the opposite of what we want when fasting or doing an FMD.

Note: Dr. Longo recommends that if you have any health problems, fasts of any kind, including FMDs, should be done under medical supervision.

Is this Smoothi3 Better than a Traditional Fasting Mimicking Diet?

Not necessarily, but it’s a very easy way of doing an FMD. In my own case, I find it much easier than a typical FMD because you only have to think about eating twice a day. And, though I can’t explain why this is, I find them more satiating than just eating the same ingredients.

The NMN and resveratrol are optional; if you include them, the smoothies should help boost NAD and activates the sirtuins.

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