My Anti-Aging and Life Extension Goals

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by Nils Osmar. January 1, 2022

My goal is to “rekindle youth” – to have the same energy, mental clarity and state of health in old age (whenever that might be) that I had when I was in my 20s or 30s. I turned 69 in December 2021 and am in good health. It appears to be working so far. More specific goals include:

  • Slowing down aging. What we call “aging” is a process of decline that most researchers would say starts when we’re in our late twenties or early thirties. If it runs its course, it leads eventually to morbidity and death. Even just slowing it without reversing it could give us an extra forty or fifty years of life.
  • Reversing any aging that’s already occurred. Dr. David Sinclair of Harvard University has said that it’ll probably be easier to reverse aging in the future than to prevent it from occurring. His lab has already succeeded in reversing aging in some tissues and organs (in animal studies). As time goes by they hope to be able to apply their research to human beings, “resetting the age” in organs such as eyes to restore vision. While we’re waiting for the results of Sinclair’s research, there are supplements we can take which can help move us some ways in that direction. I’ll list the ones I’m taking below.
  • Compressing morbidity. Researchers have found that giving lab animals a nutrient called alpha ketoglutarate, or AKG, both extends lifespan and compresses morbidity in mice (reducing the period of decline at the end of their lives from a few months to a few days). (In people, the equivalent would be living ten or fifteen years longer while staying healthy and mobile up until our last few weeks of life.) Tests are now underway to find out whether AKG has the same effect in humans, and the most beneficial dose. In the meantime, many people are taking a form of AKG called Ca-AKG in the hopes of having a similar benefit.
  • Preventing age-related muscle wasting – i.e., building and maintaining strong muscles that will last a lifetime. Exercise is key; so are supplements such as Tongkat Ali and boron that can restore hormones like testosterone to youthful levels.
  • Having strong bones and joints. Supplements such as BioGaia’s L. Reuteri 6475 can help prevent osteoporosis, a disease that weakens the bones as we age. Hyaluronic acid and other supplements can increase collagen and rebuild our joints.
  • Having healthy lungs, hearts and other organs. Avoiding cardiovascular disease.
  • Having a healthy thymus (and other glands) and a strong immune systems. Studies have shown that increasing human growth hormone to youthful levels can restore involuted thymus glands to a youthful state, and that a type of fasting followed by a re-feed can rejuvenate the immune system.
  • Having smooth unwrinkled, skin with good elasticity – and reversing any skin aging that may already have occurred, Collagen, hyaluronic acid, copper peptides and other supplements appear to help.
  • Having healthy brains and a sharp, clear minds. Sugar (in the forms of sucrose and fructose) is associated with brain aging; reducing our intake of it may help prevent dementia and Alzheimer’s.
  • Maintaining a healthy weight (not too fat, not too thin),
  • Having good eyesight.
  • Having healthy mitochondria.
  • Having good sexual health. We should be able to enjoy sex and be sexually active (if we want t0) as long as we’re around. We have many choices if we want to restore our sex hormones to youthful levels.
  • Having long telomeres. Telomeres are the “end caps” on our chromosomes; they shrink as we age. By taking supplements like astragalus or ashwagandha that increase telomerase, we can lengthen them again.
  • Having healthy levels of insulin and blood glucose. Eating a lower-carbohydrate diet and taking supplements such as berberine, milk thistle and allulose can help stave off Type 2 Diabetes.
  • Having healthy levels of cholesterol and triglycerides.
  • Having healthy blood. “Old blood factors” are associated with aging; we may may literally be able to clean old protein fragments out of our bloodstreams ad rejuvenate our blood.
  • Reaching “escape velocity”, a point at which medical technology will be able to “fix what’s going wrong with us” faster than it goes wrong. (Escape velocity (LEV) is a hypothetical state of being in which life expectancy is extended longer a year for every year that goes by – presumably by the development of new medical technologies.) Reaching it could, in theory, help us live to be 100, 200, 500 or longer in perfect health. (Immortality, anyone?) (Why not try?) 
  • Bringing some friends along on the journey.

Can we really do all of these things?

There’s no way to know the future, but I think we’ll be able to. At the least, anyone who wants to live to be 125 or thereabouts (the supposed maximum human lifespan) in good health should be able to do so. And as medical technology advances, those of us able to reach that age may be able to live much longer than that.

On a Personal Level

It’s sad seeing people I care about get old and (sometimes) die. I’m not sure what to do about that except keep educating people to the possibility that they may be able to be healthier longer if they start doing things to extend their lifespans.

Taking Care of the Environment

If the environment goes to hell, our plans to live longer will be undercut. So for both altruistic and selfish reasons I’d like to see the world move in the direction of clean air, clean water, and clean soil, and making sure we have a livable climate not only for future generations, but for ourselves and our friends and families.

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