Sea Buckthorn Berry Oil Promotes “Rapid and Selective Mobilization” of Stem Cells
- by Nils Osmar. September 14, 2023.
- This post is not intended as, and should not be taken as, medical advice.
- See full Medical Disclaimer
Want to activate your stem cells without expensive stem cell therapy? According to this 2019 study, consumption of sea buckthorn proanthocyanidins (found in the seeds and berries of the plant) leads to an increase in three types of stem cells:
- Progenitor stem cells
- Endothelial stem cells
- Mesenchymal stromal cells
Note: Sea buckthorn should not be confused with common buckthorn, an invasive weed with no particular benefits.
From the study:
Study design and methods: A randomized, double-blind, placebo-controlled, cross-over trial was conducted in 12 healthy subjects.
Blood samples were taken immediately before and at 1 and 2 hours after consuming either placebo or 500 mg SBB-PE. Whole blood was used for immunophenotyping and flow cytometry to quantify the numbers of CD45dim CD34+ CD309+ and CD45dim CD34+ CD309- stem cells, CD45- CD31+ CD309+ endothelial stem cells, and CD45- CD90+ mesenchymal stem cells.
Results: Consumption of SBB-PE was associated with a rapid and highly selective mobilization of CD45dim CD34+ CD309- progenitor stem cells, CD45- CD31+ CD309+ endothelial stem cells, and CD45- CD90+ lymphocytoid mesenchymal stem cells.
In contrast, only minor effects were seen for CD45dim CD34+ CD309+ pluripotential stem cells.
Conclusion: Consumption of SBB-PE resulted in selective mobilization of stem cell types involved in regenerative and reparative functions.
AMPK activator
Another study found that it also activates AMPK, the longevity pathway. From the study:
- •Hypolipidemic effects of SBFO extract were investigated by golden syrian hamsters.
- •SBFO extract could relieve fat accumulation and improve lipid metabolism.
- •SBFO extract could relieve oxidative stress caused by hyperlipemia.
- •SBFO extract could attenuate metabolic dysfunction through AMPK and Akt pathway.
From one (human) study:
“By documenting the ability of SBB-PE to support stem cell mobilization and to increase the number of circulating stem cells, we have uncovered a new mechanism of action behind many of the health benefits that have been historically associated with SBB, as a part of its use in Tibetan, Mongolian, and Chinese traditional medicine.”
“Once mobilized, bone marrow stem cells can participate in the process of tissue repair and modulate local inflammation, supporting the use of SBB-PE in overall health maintenance.””
Conclusion: Consumption of SBB-PE resulted in selective mobilization of stem cell types involved in regenerative and reparative functions.”
- Study: The Anti-Cancer Activity of Sea Buckthorn
- Study:Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects
My thoughts:
- IMO, sea buckthorn is key to anti-aging and stem cell mobilization.
- I’ve been taking about a gram of sea buckthorn berry oil for a couple of years. These days, I take it most mornings with my NMN and other AMPK-activating supplements.
- The berry oil appears to be more beneficial than the seed oil
- The best brand I’ve found so far is Sibu. Many other brands have a tiny amount of sea buckthorn oil in safflower oil
- I also take sea buckthorn berry powder, which I mix into a smoothie.
- Sea buckthorn is also an excellent source of Omega 7 fatty acids.
Not medical advice
This article is not intended as, and should not be taken as, medical advice. I’m not advising that people eat any particular diet or take any particular supplement(s), just reporting on what I’m doing. Supplements, like medications and other interventions, can have side effects; I would encourage people to research both possible benefits and side effects before starting on any supplementation regimen, and consult with a medical professional about any issues which might have a medical component. See full Medical Disclaimer
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