My Supplements: NAD Boosters and Sirtuin Gene Activators

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by Nils Osmar. Updated May 25, 2022

I take lots of supplements! The types I take include:

This page has information about the NAD boosters and sirtuin activators.

Short version – I take the following supplements most mornings:

  1. NMN powder (DoNotAge) – 1500 mg.
  2. Resveratrol (DoNotAge) – 500 mg (three days a week)
  3. SIRT6 Activator (DoNotAge) – 2 capsules
  4. Black Elderberry Extract (Gaia Herbs) – 1 teaspoon
  5. TMG (DoNotAge)  – 500 mg
  6. Ubiquinone (COQ10) (Jarrow) – 100 mg. 
  7. PQQ (Health Through Nutrition) – 20 mg
  8. Glucosamine/chondroitan/MSM (Jarrow) – 4 capsules
  9. Astaxanthin – BioAstin – 3 or 4 capsules
  10. Optional: Apigenin – DoNotAge – 500 mg
  11. Optional: DoNotAge NR – 500 mg
  12. I’ll sometimes take them along with a fasting mimicking smoothie.

For more details about the above supplements, scroll down. (NOTE: I also take some testosterone boosters and hGH boosters and supplements for brain and skin health. See this page.)

NAD (nicotinamide adenine denucleotide) – NAD (or NAD+) is a coenzyme central to metabolism. It boosts memory, improves mental clarity, improves mood and concentration, boosts neurological function, reduce symptoms of depression, and facilitates DNA repair.

By the time we’re in our forties, levels of NAD have fallen to half of what they were when we were young. They continue to decline as the years pass. We can raise NAD by taking NAD precursors, fasting, taking saunas and cold showers, and exercising. A recent study demonstrated that a few weeks of resistance training raised the NAD levels of non-athletes in their 60s to the levels of athletes in their 20s.

The NAD Boosters I’m Taking

Some of these are NAD boosters or precursors. Others are supplements that support mitochondrial health.

  1. NMN (DoNotAge) – NMN is a NAD precursor. NAD molecules are too big to fit through cell walls. Research has shown though the NMN can pass through the walls with the help of a transporter in the human gut, where the NAD is assembled into NAD. I take 1.5 grams of DoNotAge NMN
  2. Resveratrol (DoNotAge) – (activates sirtuin genes) I’m currently taking 500 mg. There’s some evidence that larger doses may be toxic. (I take 500 mg of resveratrol just three days a week.)
  3. SIRT6 Activator (DoNotAge) ––  (made from fucoidan, from brown seaweed.) To me this is one of the most important supplements I’m taking. Fucoidan has been found to activate SIRT6. This supplement is a source of it. DoNotAge has stated that they test every strain of seaweed they put in SIRT6 Activator to verify that it actually is activating the SIRT6 gene, which is deeply associated with life extension. It’s only available by subscription on their website. Some other companies also make fucoidan extracts, but don’t guarantee it’s activating SIRT6. (You can also activate sirtuin 6 to some extent by eating lots of wakame, a type of seaweed. I make it a regular part of my diet). 2 capsules.
  4. Black Elderberry Extract (Gaia Herbs) – has also been found to activate SIRT6. 1 teaspoon.
  5. TMG (DoNotAge)  – TMG restores methyls used up when NMN, niacin, NR or other NAD precursor molecules are metabolized) (0.5 gram)
  6. Ubiquinone (COQ10) (Jarrow) – supports mitochondria; improves NAD+/NADH ratio. 100 mg. 
  7. PQQ (Health Through Nutrition) – triggers mitochondrial biogenesis (works in conjunction with CoQ10) (20 mg)
  8. Apigenin – Apigenin prevents an enzyme called CD-38 to destroy NAD in the body. So it’s as important, in my opinion, as taking precursors. I’ll sometimes take an apigenin supplement (from Donotage) with my NAD boosters in the morning; other times, I might eat some parsley or celery (food sources of apigenin) or drink some chamomile tea (another source) in the afternoon. 500 mg.
  9. Glucosamine/chondroitan/MSM (Jarrow) – 4 capsule. Glucosamine is a potent sirtuin gene activator. It also promotes the differentiation of stem cells, activates AMPK and supports deep autophagy.

Other NAD Boosters

These supplements also boost NAD levels or activate the sirtuin genes. I’ll occasionally add them to the cocktail.

  1. MCT OIL: improves NAD+/NADH ratio (I usually mix a scoop of MCT oil powder in my coffee) (There’s also evidence that the ketones our bodies make when we use MCT oil may be protective against Alzheimer’s and other forms of dementia.) I’m not currently taking MCT oil
  2. Quercetin and Fisetin. Fisetin and Quercetin are both senolytics, meaning that they both activate the sirtuin genes and kill senescent cells. I don’t take them every day but will take a “blast” of 5 capsules of each once a month or so. There are lots of good companies for these two compounds; I’m getting mine currently from DoNotAge.
  3. Rutin – also activates sirtuins. I’m not currently taking it.
  4. Alpha Lipoid Acid – improves NAD+/NADH ratio (1200 mg).
  5. Pau D’Arco– rich in D. lapachone; improves NAD+/NADH ratio.

Where to Buy NAD Boosters

  • I mentioned several good companies in the notes above. I’m currently obtaining most of my NAD boosters from DoNotAge.
  • DoNotAge is the sponsor of my Youtube channel, Pathways to Longevity. As part of that arrangement, they have a discount code, PATHWAYS (in all caps). The code gives 10% off of all products on their website.
  • If you decide to buy supplements from them and use the discount code, my channel will receive a small payment. This also supports my having the time to put in on this website.
  • NAD Boosters are not cheap. For buying the key ones, such as NMN ad resveratrol, I would recommend buying the powders. The price is a little steep but it comes to a lower cost per gram. One bottle of DoNotAge’s resveratrol has last me over a year.
  • See this page for more information.

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One Comment

  1. PAOLO FIORE says:

    Hi, why don’t you take quercetin and fisetin every day but prefer to take a “blast” of 5 capsules each about once a month?

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