The Most Important Anti-Aging Intervention?

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by Nils Osmar. August 14, 2022. Medical Disclaimer

According to a recent human study, elderly men and women given a compound called GlyNAC (composed of equal parts glycine and NAC) experienced striking improvements in:

  • Stem cell fatigue
  • Cellular senescence
  • Muscle strength
  • Gait speed
  • Exercise capacity
  • Waist circumference
  • Blood pressure.
  • Oxidative stress
  • Glutathione deficiency
  • Mitochondrial dysfunction
  • Mitophagy (removal of damaged mitochondria from the body)
  • Inflammation
  • Insulin resistance
  • Endothelial dysfunction
  • Genomic damage
  • Cellular senescence
  • Muscle strength
  • Gait speed
  • Exercise capacity
  • Waist circumference
  • Blood pressure.

Note again that this was a human study, which gives it higher ranking than the animal studies often cited in support of other anti-aging compounds. To read the study itself, go to: Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial

More details

The study was summarized in an article called “GlyNAC supplementation reverses aging hallmarks in aging humans“. From the article:

“A randomized, double blind human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC – a combination of glycine and N-acetylcysteine – improves many age-associated defects in older humans and powerfully promotes healthy aging.

“This is relevant because until now, there have been no solutions toward improving many of these age-related declines in people.

“This is the first randomized clinical trial of GlyNAC supplementation in older humans, and it found that a wide variety of age-associated abnormalities improved in older adults supplemented with GlyNAC, while no improvements were seen in those receiving placebo…”

Increasing lifespan

Other recent studies have shown that the compounds found in GlyNAC (glycine and NAC), when taken together in equal amounts, increases lifespan in animals. See study: Glycine and N-Acetylcysteine (GlyNAC) Supplementation: Can it increase Life Span?

Life extension of course can’t be proven in humans because it would take longer than a human lifespan to prove it. But its other effects have been verified by this and other studies as occurring in both humans and animals. The mechanism for all of GlyNAC’S benefits appears to be the restoration of glutathione to young adult levels.

My thoughts:

  • In animal studies in which animals were given GlyNAC, researchers have seen a significant increase in lifespan.
  • Lifespan can’t be measured directly in humans but this study suggests that the same mechanisms that increase lifespan in animals are occurring in humans, so there’s reason to believe that life extension in humans could also be a “side effect” of supplementing with the component amino acids in GlyNAC.

What I’m doing:

  • To me, restoring glutathione to young adult levels is a key part of my personal anti-aging strategy. I would rank it up there with activating the sirtuin 6 gene and restoring AKG levels, as essential anti-aging interventions.
  • To activate the SIRT6 gene, I’m taking a form of fucoidan which has been shown in lab studies to switch sirtuin 6 on, along with a black elderberry extract (rich in cyanidin, which some studies have shown also activates SIRT6). The fucoidan I’m taking is DoNotAge’s SIRT6 Activator. The cyanidin I’m taking is Gaia Herbs’ Black Elderberry Syrup. I take both supplements along with DoNotAge’s NMN because NMN increases NAD levels which the sirtuin genes use as fuel.
  • To replenish AKG levels, I’m taking both a Ca-AKG (calcium AKG) supplement from DoNotAge and an AAKG supplement from Nutracost.
  • To restore glutathione, I’m taking a whey supplement in the mornings after my workouts, and taking LifeExtension NAC along with NOW Foods glycine in the evenings. (Pure Encapsulations sells a GlyNAC powder which I’m also thinking of trying soon.) I find that taking NAC with glycine in the evening also supports better sleep.
  • In addition to taking supplements, I’m of course also still doing resistance trainingt; eating high nutrient meals rich in protein, including leucine; balancing the activation of AMPK (the longevity pathway) and mTOR (the growth pathway); and doing a lot of fasting to activate the sirtuins and autophagy. See my full protocol on this page.
  • In this article and others on this website, I’m reporting on what I’m doing, not suggesting a course of action for others. Supplements and medications can have multiple effects in the human body. Everyone should read up on both their potential benefits and side effects before taking them. What’s safe and effective for one person may not necessarily be for another. The articles on this website are not intended as, and should not be taken as, medical advice. See full Medical Disclaimer.

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Other resources

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More about glutathione:

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