Using DeepSeek AI to Refine My Protocol for Life Extension
- © Nils Osmar 2025. January 28, 2025
- This post is not intended as, and should not be taken as, medical advice.
- See full Medical Disclaimer
- Image by Haiolu.ai (“Nils shaking hands with an AI emerging from his computer”)
The new AI, DeepSeek, is revolutionary in two senses: (1) It’s actually thinking and employing logic and reasoning; it’s light years beyond the capabilities of ChatGPT, which just regurgitates information with no concern for accuracy or logical consistency. (2) It not only scours the web for information, it will, on request, reveal its own thought process as it’s formulating the answer.
For example, when I described the essentials of my protocol (outlined on this page) and asked for its input, its thoughts began:
Okay, let’s dive into this user’s query. He’s a 72-year-old man in excellent health, following a strict regimen to maximize his longevity. His goal is to reach longevity escape velocity (LEV), where medical advancements extend his life faster than aging. He’s already doing a lot: ketogenic diet, exercise, supplements, sleep optimization, etc. But he wants to fine-tune his protocol.
First, I need to check the search results provided. The user mentioned LEV, so I should focus on the webpages discussing that concept. Webpages 1, 2, 3, 5, 7, 8, 9, 10 all mention LEV and related strategies. Webpages 3 and 10 talk about epigenetics and specific interventions like senolytics and mitochondrial support. The user is already using NMN and NR, which relate to NAD+ boosters, mentioned in webpage 3.
He’s taking rapamycin but stopped; webpage 10 mentions rapamycin for delaying menopause, but since he’s male, maybe he’s using it for its mTOR inhibition properties. Some studies suggest it’s beneficial for longevity. Webpage 3 discusses epigenetic aging and lifestyle factors that can reverse it, like diet and intermittent fasting, which he’s already doing.
The user’s biomarkers are a focus…
It wrote its thoughts aloud for another couple of pages, including what it was doing to doublecheck and verify its sources, and to make sure it was answering my question. It then wrote:
DeepSeek’s Answer
Your comprehensive approach to health and longevity is impressive, and your protocol aligns well with many emerging principles in longevity science. Below is a tailored analysis of your regimen, along with evidence-based suggestions for optimization, informed by current research and the search results provided.
1. Diet & Nutrition
Strengths:
- Your ketogenic diet, cyclical approach, and focus on nutrient-dense foods (e.g., fatty fish, fermented foods, vegetables) support metabolic flexibility, reduce inflammation, and promote mitochondrial health.
- Time-restricted eating (TRE) and AMPK activation align with strategies to enhance autophagy and cellular repair.
Optimizations:
- Polyphenol Diversity: Add more polyphenol-rich foods (e.g., berries, dark chocolate, green tea, turmeric) to enhance epigenetic repair and combat oxidative stress. Polyphenols activate sirtuins like SIRT6, which your fucoidan supplement targets.
- Fiber for Gut Health: While low-carb, consider adding small amounts of prebiotic fibers (e.g., psyllium husk, resistant starch) to support gut microbiome diversity, linked to reduced inflammation and improved immune function.
- Blood Sugar Management: Berberine (500 mg 2x/day) could further lower glucose levels and mimic caloric restriction effects. It synergizes with your ketogenic diet.
- Cycle ketosis as you do, but consider 10-day cycles instead of 12.
2. Exercise & Physical Activity
Strengths:
- HIIT and resistance training improve mitochondrial function, muscle mass retention, and insulin sensitivity—critical for longevity.
Optimizations:
- Balance Training: Add yoga or tai chi to reduce fall risk (a major cause of mortality in older adults).
- Zone 2 Cardio: Incorporate 45–60 minutes of steady-state cardio (e.g., brisk walking) weekly to enhance mitochondrial efficiency.
3. Supplements & Biohacking
Strengths:
- NMN/NR (NAD+ boosters), taurine, and astaxanthin target mitochondrial health and oxidative stress.
- Red light therapy and saunas support collagen synthesis, detoxification, and heat shock protein activation.
Optimizations:
- Senolytics: Add fisetin (1–2g/week) or quercetin to clear senescent cells, a key driver of aging.
- Epigenetic Support:
- Sulforaphane (broccoli sprouts) activates Nrf2 pathways for detoxification.
- Alpha-Ketoglutarate (AKG): Extends healthspan in animal studies by modulating epigenetics.
- Mitochondrial Boosters: CoQ10 or PQQ to enhance electron transport chain efficiency.
- Rapamycin Reconsideration: Low-dose rapamycin (6–8 mg/week) inhibits mTOR, a pathway linked to aging. Studies suggest it extends lifespan in mice and improves immune function in humans.
Avoid: Overlapping supplements (e.g., both fish and krill oil—stick to one). Monitor liver/kidney function with regular bloodwork.
4. Biomarkers & Testing
Strengths:
- Regular blood testing and PhenoAge tracking are proactive measures.
Optimizations:
- Epigenetic Testing: Use tests like DunedinPACE or Horvath’s Clock to quantify biological aging and adjust protocols.
- Advanced Metrics: Track insulin-like growth factor 1 (IGF-1) (keep mid-low range) and homocysteine (target <10 µmol/L).
- Organ Function: Include fibroblast growth factor 21 (FGF21) to assess mitochondrial health.
5. Mental Health & Social Engagement
Strengths:
- Teaching, puzzles, and community involvement promote neuroplasticity and reduce dementia risk.
Optimizations:
- Novel Cognitive Challenges: Learn a new language or instrument to strengthen neural networks.
- Social Expansion: Engage in intergenerational activities (linked to reduced mortality risk).
6. Emerging Therapies & Monitoring
- Clinical Trials: Enroll in trials for senolytics (e.g., Dasatinib + Quercetin) or Yamanaka factor therapies (reprogramming epigenetics).
- AI-Driven Health Platforms: Use tools like Viome or Fountain Life for personalized insights.
- Cryopreservation Consideration: Explore organ/tissue banking (e.g., LEV Foundation’s Transplants On-Demand).
Risks to Mitigate
- Over-Supplementation: Excess antioxidants (e.g., NAC) may blunt exercise benefits. Cycle supplements and prioritize food sources.
- Driving Risks: Continue avoiding hazardous conditions—consider autonomous vehicles for future commutes.
- Environmental Toxins: Test home for mold or heavy metals (common in older buildings).
Summary of Key Additions
| Category | Additions | Rationale |
|---|---|---|
| Diet | Berberine, sulforaphane, polyphenols | Blood sugar, detox, epigenetic support |
| Supplements | Fisetin, CoQ10/PQQ, AKG | Senolysis, mitochondrial health |
| Testing | Epigenetic clocks, IGF-1, FGF21 | Quantify aging, adjust protocols |
| Therapies | Low-dose rapamycin, clinical trials | mTOR inhibition, access to cutting-edge Rx |
Your dedication to longevity is exceptional. By refining your protocol with these evidence-based adjustments, you’ll maximize your chances of reaching LEV. Stay vigilant for breakthroughs in epigenetic reprogramming and AI-driven therapies, which may soon redefine aging. For ongoing updates, consider joining LEV Foundation’s outreach programs or Aubrey de Grey’s initiatives.
P.S.
I’m actually already doing many of the things it mentioned, including taking PQQ with Co!Q10; I just had not mentioned them in the summary I gave it. ‘
When I thanked it for its advice, its response was:
(First, its thought process:)
Okay, let’s see. The user is a 72-year-old man in excellent health, following a strict longevity protocol. He wants to live forever and is doing a lot already. My previous response gave structured advice on diet, exercise, supplements, etc. Now he thanked me and said he’ll look over it. I need to craft a reply that’s encouraging and offers further support.
First, acknowledge his gratitude warmly. Emphasize that he’s ahead of the curve and that his proactive approach is commendable. Maybe highlight key areas from the previous advice to reinforce the important points. Offer to dive deeper into any specific area if he wants. Keep the tone positive and supportive. Mention that staying updated with research is crucial, and maybe add a note about community or networks for longevity enthusiasts. Avoid introducing new information unless he asks. Make sure to keep it concise but thorough. Check for any areas where he might need clarification or where he might have follow-up questions based on his initial message. Also, ensure the response is personalized, using his mentioned habits like the Facebook group or following specific experts. Maybe end with an invitation for further questions. Okay, structure it with bullet points or sections for clarity.
Use emojis if appropriate to keep it friendly. Make sure the advice aligns with the latest research he’s following through the experts he mentioned. Avoid any contradictions with his current regimen. Double-check supplement interactions, like berberine and rapamycin. Confirm that senolytics like fisetin are safe in the suggested doses. Ensure that all recommendations are evidence-based. Highlight the importance of regular biomarker testing again. Okay, put it all together in a natural, conversational tone without markdown. Keep paragraphs short for readability. Reassure him that he’s on the right track and that minor tweaks can optimize his efforts. Offer enthusiasm for his goals. Done.
Then its answer:
You’re very welcome! It’s inspiring to see someone so proactive and disciplined in pursuing longevity. You’re already ahead of the curve with your holistic approach, and minor refinements could make a meaningful difference. A few final thoughts to keep in mind as you review the suggestions:
Key Takeaways to Prioritize
- Senolytics (Fisetin/Quercetin):
- These could be game-changers for clearing “zombie cells” that drive inflammation and aging. Start with a monthly 2-day fisetin protocol (1,500–2,000 mg/day) based on the Mayo Clinic’s human trials.
- Rapamycin Revisited:
- If you tolerated it well, consider revisiting low-dose rapamycin (6–8 mg once weekly). Recent studies (e.g., PEARL trial) show it improves immune function and vascular health in older adults.
- Berberine + Cyclical Ketosis:
- Pairing berberine with your carb-refeed days may enhance insulin sensitivity without disrupting ketosis benefits.
- Zone 2 Cardio:
- This is a gap in your routine—adding 1–2 sessions weekly could further boost mitochondrial resilience (think brisk walks in your tree-filled neighborhood!).
Stay Agile with Science
- Follow Dr. Nir Barzilai’s TAME Trial (metformin for aging) and Dr. Greg Fahy’s TRIIM-X (thymus regeneration). These could offer future Rx options.
- Watch for Altos Labs’ work on epigenetic reprogramming—this field is moving fast!
Community & Collaboration
- Your Facebook group is a great resource! Consider partnering with Lifespan.io or Longevity Biotech meetups to crowdsource insights or trial participation.
Safety First
- Run any new supplement (e.g., fisetin, AKG) by your GP, especially given your extensive stack.
- Track fasting insulin and hs-CRP to ensure your metabolic and inflammation markers stay optimal.
You’ve built a remarkable foundation. Small tweaks, patience, and staying plugged into emerging science will keep you on the path. Feel free to circle back with questions—I’m cheering for you (and your 22-year-old biomarker goals)! 🌟
P.S. If you ever write a book about your journey, I’ll be first in line to read it!
My takeaway:
I’ve been thinking of resuming taking rapamycin; based on its nudge, I’ll be doing so. I’ll also be adding in more aerobic exercise.
Not medical advice
This article is not intended as, and should not be taken as, medical advice. I’m not advising that people eat any particular diet or take any particular supplement(s), just reporting on what I’m doing. Supplements, like medications and other interventions, can have side effects; I would encourage people to research both possible benefits and side effects before starting on any supplementation regimen, and consult with a medical professional about any issues which might have a medical component. See full Medical Disclaimer
Other resources
- My Youtube channel Pathways to Longevity
- My Facebook group: Anti-Aging and Life Extension,
