- by Nils Osmar. September 22, 2023
- This post is not intended as, and should not be taken as, medical advice.
- See full Medical Disclaimer
I was thinking this morning about how a number of people in our community are immortalists — believing, or at least hoping, that aging can be stopped and reversed and will no longer be a cause of death.
If this happens, we may have a shot at actual physical immortality (as long as we can keep from being killed by other things).
One unanswered question is: Is this a far-off vision of a future that may still be decades or centuries away? Or could today’s anti-aging interventions, if we apply all of them, get us to physical immortality?
- My knee-jerk reaction is to say, “No, they’re just buying us time.”
- This. isn’t to say they’re of no value. If we apply what we know now, we can probably live to 120 or so in good health. But to live beyond that, we’ll need medical interventions that may or may not occur during our lifetimes.
- But sometimes I think that applying what we know now might actually “get us there.”
What do we know?
Quite a bit, actually, For example:
- We know that compounds like NAD+, Nitric oxide, glutathione, AKG, human growth hormone and testosterone and other sex hormones decline during age, in ways that correlate with the progression of the aging process — and more importantly, we know how to restore them all to youthful levels.
- We know how to activate the sirtuin genes, in particular sirtuin 6, which has been shown to extend lifespan significantly in lab animals.
- We know how to use saunas and hot baths to increase heat shock proteins, and about the parallel benefits of cold exposure and other hormetic interventions.
- We have access to compounds like rapamycin (which has been found to extend lifespan reliably and reproduceably in multiple species of animals), and also ones like berberine, glucosamine and metformin which can dampen the activation of mTOR (a pro-aging pathway, which is necessary for life and health, but associated with shorter lifespans) and fuel the activation of AMPK (a pathway associated with life extension).
- We know how to lower blood glucose, prevent damage from advanced glycation end products, and greatly reduce our odds of dementia.
- We have supplements and other interventions that are anti-cancer and protective against cancer, diabetes and heart disease.
- For the rich, we have stem cell therapy, which has some dangers but also shows promise of being genuinely rejuvenation
- We have interventions on the horizon such as Katcher’s E5 and various ways of cleaning “old blood factors” out of our blood.
One answered question is:
- What would happen if we were to apply all of these?
- Each of them addresses a part of the overall process known as aging. Could the whole be greater than the sum of the parts?
- This is what I’m trying to do at the moment in my own protocol.
- There’s no guarantee that it’ll work, but who knows? Perhaps it could.
- For more information about what I’m doing and how it’s going so far, see this page.
- And feel free to share your own thoughts below.
Not medical advice
This article is not intended as, and should not be taken as, medical advice. I’m not advising that people eat any particular diet or take any particular supplement(s), just reporting on what I’m doing. Supplements, like medications and other interventions, can have side effects; I would encourage people to research both possible benefits and side effects before starting on any supplementation regimen, and consult with a medical professional about any issues which might have a medical component. See full Medical Disclaimer
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